Endocrine Abstracts

Increased activity of sympathetic nervous system (SNS) was observed in early stage of hypertension onset. The aim of our present study was to estimate catecholamines response to stress stimulus (insulin induced hypoglycaemia) in young males with early diagnosed non-treated hypertension grade 1 (HT) and normotensive controls (NT).Methods: Insulin tolerance test (ITT, 0.1 IU/kg body weight, Actrapid HM, i.v.) was performed in 21 HT male subjects aged 20.0&...

Growth hormone deficiency (GHD) in adults seems to predispose to insulin resistance (IR). Development of GHD related IR could be associated with adipose tissue (AT) derived signals. To investigate the nature of this pathological regulation we 1) measured gene expressions for leptin, adiponectin, TNFalpha, IL-6, 11beta HSD1, SREBP, PPARgamma in the AT of untreated GHD adults, and 2) assessed effect of euglycemic hyperinsulinemia (HI) at the gene level.Met...